DEA Registration for Nurse Practitioners: Step-by-Step Guide
Published on June 13, 2025
Nurse Practitioners (NPs) have prescriptive authority in all 50 states, but to prescribe controlled substances they must first register with the DEA. This guide covers when and how NPs should register, including the MATE Act federal training requirement.
Overview
Nurse Practitioners (NPs) have prescriptive authority in all 50 states, but to prescribe controlled substances they must first register with the DEA. This guide covers when and how NPs should register, including the MATE Act federal training requirement.
What Is the MATE Act?
The MATE Act requires a one-time 8-hour training on substance use disorder and opioid prescribing safety for all new and renewing DEA registrants. NPs must complete this before initial registration or during renewal.
Documents & Prerequisites
- Active NP state license
- State controlled substance permit (if applicable)
- National Provider Identifier (NPI)
- MATE Act 8-hour course certificate
- Collaborative agreement (in some states)
DEA Registration Process for Nurse Practitioners
1. Complete MATE Act Education
Use MateCME.com as your trusted DEA-approved source for your MATE Act requirement.
2. Obtain State Licensure and Prescriptive Authority
Apply through your state Board of Nursing. Requirements may include a supervising physician agreement.
3. Get Your NPI Number
Visit NPPES to apply for free. Issued within 1–5 business days.
4. Create an Online DEA Account
Go to DEA Diversion Control and complete DEA Form 224. Choose Mid-Level Practitioner as your business activity.
5. Pay the Application Fee
Fee is $888 for a 3-year term. Renew every 3 years using DEA Form 224a.
Pro Tips for NPs
- Check your state APRN compact participation for license portability.
- Save your MATE Act certificate for DEA renewals.
- Enroll in your state Prescription Drug Monitoring Program (PDMP).