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    DEA Registration for Physician Associates: A Complete Walkthrough

    Published on June 13, 2025

    Physician Associates (PAs) often prescribe medications including controlled substances. To do so legally, PAs must complete DEA registration. Here is everything PAs need to know, from meeting the MATE Act requirement to completing Form 224.

    Introduction

    Physician Associates (PAs), also known as Physician Assistants, often prescribe medications including controlled substances. To do so legally, PAs must complete DEA registration. Here is everything PAs need to know, from meeting the MATE Act requirement to completing Form 224.

    MATE Act Summary

    The 2023 MATE Act mandates that all healthcare professionals registering with the DEA complete 8 hours of education on treating patients with opioid or substance use disorders. This must be completed before initial registration or at renewal.

    Eligibility Checklist

    • State PA license
    • State CS license (if applicable)
    • NPI number
    • MATE Act course certificate
    • Supervision agreement (varies by state)

    DEA Registration: Step-by-Step for PAs

    1. MATE Act Training

    Use MATECME.com to satisfy the DEA MATE Act requirements. Complete the 8-hour requirement and retain your certificate.

    2. Apply for a State License

    Board certification (PANCE) and background check required. Apply through the state licensing body for PAs.

    3. Obtain Your NPI

    Apply via NPPES. Free and usually issued within 1–3 business days.

    4. Complete DEA Form 224

    Visit the DEA website and choose Mid-Level Practitioner. Select drug schedules II–V and enter your license, NPI, and practice address.

    5. Pay the Fee and Submit

    Fee is $888 for three years. Processing takes 4–6 weeks. Renew every 3 years using Form 224a.

    Important Considerations for PAs

    • Check if your supervising physician DEA registration is required.
    • Many employers will help with the process.
    • Keep your MATE certificate for future audits or renewals.