DEA Registration Guide for Doctors of Osteopathic Medicine (DOs)

Introduction

Doctors of Osteopathic Medicine (DOs) must register with the DEA to legally prescribe Schedule II–V medications. This guide explains when and how DOs should register and meet all federal requirements, including the MATE Act.

What is the MATE Act?

The Medication Access and Training Expansion (MATE) Act, enacted in 2023, mandates that all DEA registrants complete 8 hours of education focused on substance use disorders and opioid prescribing best practices. This is a one-time training requirement.

Required Credentials

• Unrestricted DO license in the practicing state
• State Controlled Substance License (if required)
• National Provider Identifier (NPI)
• MATE Act training certificate

Step-by-Step DEA Registration for DOs

1. Complete the MATE Act Training

Use MATECME.com to satisfy the DEA MATE Act requirement. Training must cover safe opioid prescribing and addiction management.

2. Obtain Your State DO License

You must be licensed in the state where you plan to prescribe. Submit credentials to your state osteopathic board including COMLEX scores and residency proof.

3. Get Your NPI Number

Visit NPPES to apply. Required for both billing and DEA registration.

4. Complete DEA Form 224

Go to DEA Diversion Control. Indicate your profession as Practitioner and select Schedules II–V.

5. Pay the Application Fee

Fee is $888 for a 3-year term. Pay online via debit or credit card.

6. Submit and Await Approval

Processing typically takes 4–6 weeks. Renew every 3 years using Form 224a.

Additional Tips for DOs

• Apply at least 2–3 months before beginning practice.
• Employers may reimburse the application cost.
• Keep all compliance documentation organized.